Mostly a copy/paste from earlier thread, but a few other thoughts tossed in the mix.
As much as I love my boys in Pitt I can't see them pulling out a win against the Jags. The loss of Aaron Smith at DE has devastated their ability to stop the run, their pass rush has virtually disappeared as well. The Jags exploited that hole a couple of weeks ago and will do so once again, look for them to have major success running to the left side.
Pitt's O-line problems have only gotten worse. Weakest point has been left tackle, their backup Max Starks was lost for the season in the last regular season game against Baltimore. They are down to the 3rd string guy there, and only have one other healthy linemen. There has been some talk that they will move Alan Faneca to left tackle, probably not a bad idea but it still leaves a 3rd (Trai Essex) stringer at left guard. He has had one start in the past two years, lovely. The other injuries in the secondary and backfield only add to their woes, too many starters on IR and backups injured as well.
They seem to have finally fixed their return coverage issues, but that's a moot point considering the problems they have on offense/defense at this stage in the game. It's amazing Ben had such a great season given the poor protection all year, but I don't think he's gonna be able to do enough to get it done against a stout Jags team.
I'm just hoping Pitt can get out of this game without any more serious injuries that will affect next year. They will likely lose Faneca and need to rebuild the left side of their O line. Considering that problem and the schedule for next season I would not be surprised to see them finish @ 8-8, or worse.