Sounds like you have some tough decisions. I made a similar decision a few years back when I decided to move from California to Anchorage, AK. I really wanted out of California, and an opportunity presented itself. I was getting offered a job, and I had just a few days to decide, then a couple weeks to figure out where I'd live and some travel time. Other than my job contact, I had no family or friends up here.
One of the big things I had to consider was an "escape" plan. You know, if things didn't work out what would I do? I did get my friends and family involved so I had a safety net in place. Luckily, everything is working out great, and I currently love it up here. One of the best decisions I've made in life.
I say go for it. I have some friends in Denver who really love the place. With all the things going on in your life, it sounds like you need a change.