Game doesn't run too well on my 680. I have limited it to medium textures (which is worse than the consoles) and then otherwise its a mix of ultra and high. Frame rate is in the 45-60 range most of the time, which at least with gsync is smooth enough but its disappointing to find it can't utilise SLI and hence is running like I had a mid range card from 2 years ago. By the time Nvidia releases SLI drivers for it I'll have been done with the game, as is so typically the case when they aren't there on release day (shame on your Nvidia, its even one of your sponsored games as well).
The game is OK, I like killing orks but I can't say I am very good at the big fights. At least I have stopped trying to go for the ground kills when outnumbered, they do die without it which wasn't obvious in the beginning when they explained the combat system.