I have a MS intellimouse explorer and it would disconect from my usb. Sometimes it would reconnect right away, but my custom button settings would be lost and it would just operate like a 2 button mouse. Then sometimes it would disconnect and not reconnect. This doesn't happen to any of my other usb devices, so I'm wondering if it's the mouse, or possibly the motherboard or OS. I've tried using other ports and the same thing happens.