I have the GD65. It was not my first choice but the board I wanted was not available (and is still not available). The build was clean and I had no issues but have a few comments:
documentation is a bit weak (esp if things do not work out of the box); I.e, the board has virtually no diagnosis so those with problems are fairly loss (i read the support boards and the most common issue seems to be ram incompatibility which results in reboot loop). The board will beep on boot up if you have usb devices plugged in. In theory the beeps have other meanings but none of this is documented so who knows.
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Only other real complaint is that jfp2 blocks the second video card. This is minor irritation and I've studied various boards layout as to why this happened (compare the layout of the gd65 to the asrock extreme 4 or biostar xle and you can see exactly what msi did and why). The vendor fix would be to supply a 90% adapter (similar to sata ports) or for the user to pend the pins (for me the only one that care about is the power led).
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The live update feature is basically broken so I don't use it; also the most important drivers can be obtained directly from the vendor (intel, realtek, ...). The most important thing to update if yuo have issue is the bios and they strongly recommend you use usb and not live update (see
http://forum-en.msi.com/index.php?topic=113295.0 which is a user forum not official company view).
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The only outstanding issue i have is that if the system enters sleep mode while under full load (running prime95 for exampel) it will turn off rather than go to sleep (bsod). If idle it will do the proper thing. Not sure this is an msi issue but not sure it is not an msi issue.
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Other than those comments no complaints; if it stay stable for the next couple of years i'll be happy.