Sun has multiple connectors for their proprietary graphics cards in a few of their workstations. I've heard rumors of a few rare Itanium workstations that were made with dual AGP slots (not sure if this system is real, but apparently the latest AGP spec allows for it in theory). I'm sure someone will make a motherboard with multiple PCI-Express x16 slots, but whether the public will be able to buy it or not is anyone's guess (e.g. 8-way Xeon boards are made, but try to order one from Newegg).
BTW, PCI-X is the latest revision of "normal" PCI 64 bit, that runs at up to 133MHz. PCI-Express is properly abbreviated PCI-E, and is an entirely different animal.