Need to win in one league this week just to stay in playoff contention. Russell Wilson or Alex Smith?
You have to play your studs. Smith only had 17 points in their last meeting and really has never broken 20 points unless it was a subpar team. Against good defenses, Smith doesn't do much from a fantasy perspective. Case in point: Sea - 5pts, @Buf - 17, StL - 13, @SF - 12.5, @Den - 17. That doesn't leave me with a lot of confidence, even at Arrowhead.
Looking at Wilson's track record this year, he's actually performed against a few tough defenses that stop (and I use that term loosely with Beast Mode) the run. For example, Ari - 23.9, Den - 29.1. My only concern is SF's pass rush, but he has also torched good pass rush teams like KC and St.L. His upside is much higher than Smith's and he can beat any defense with his legs. I think you have to go with the stud here.