The b-21 trick was really most useful in "tricking" a motherboard into detecting the CPU as one that was supposed to run on 100MHz fsb, vs. 66MHz. This applied to Celerons. That is how people were getting the 300a to run at 450 on BX boards that offered no such bios setting.
To the best of my knowlege, there was never a way to unlock multipliers on any Intel CPU, once they started locking them.
If anyone ever tells you they have a PIII 500, as example, that's not locked, it's an engineering sample.