My opinion on the matter is all I can offer. I suspect that no true objective observations can support any opinion. I think that if you will make backups, the partitioning helps you. If a smaller drive is involved, it's easier and faster to back it up.
I make the first two partitions the keys, since they are at the outside edge of the drive, where access is supposed to be faster, and I make the boot partition "small" (4-6 GB's, depending on total Hdd size). Then I set up a dedicated swap file (page file, same difference) in the next partition. Whether or not the "main" partition is just one big single unit or broken down further between applications and user data files is another opinion item. I think for backing up my data files, I like a separate partition for those.
:thumbsup: