Hi,
I do mainly aggree with the yes, but not so completly.
As the access time from clock was getting shorter for PC133, on bad designed PC66 Systems you can run into problems with the Hold time of the data (tOH).
If the system is strobing to late, then the data are not valid any more.
This is one think I can imagine what could happen. I'm sure, there are other things, but I expect this kind of stuff only for bad system design.
ruckb