1.) Graphics don't load in firefox, but work in IE.
2.) The top and bottom navigation graphics cut off instead of blending into the background, making the page look like it's not completely loaded. If you're going for the look where the page is just floating in white space you probably want to add white space to the top.
3.) The right hand flash graphic which is continuously changing is extended over the edge of the page and doesn't line up.
4.) The center frame is just disorganized. Announcements, which are presumably more important than anything else in that section, command about 1/5th of the space and the rest is dedicated to a mission statement, a button advertising help for Tsunami victims, and such which is very disorganized AND hard to read.
5.) Top/bottom colors don't work very well together.
Essentially, what needs to be DRASTICALLY changed is the middle frame. The top & bottom are acceptable but the middle is just atrociously disorganized.
Edit: The graphics DO eventually load in FF but it's VERY slow.