At home of course not but in public places including my office I will use the covers when available and TP when there are no covers. I know someone who works in the medical profession and carries these Clorox wipes (they come in a small pocket size package). I think that's a little overboard but if you knew what types of bacteria and diseases you can get from a toilet seat, you may reconsider. But then again, most public handled items are pretty nasty with lots of dangerous pathogens. I take public transportation every day and whenever I reach my destination, home or work, I wash my hands and sometimes my face. NYC subways are filthy.