Fill tank till pump turns it off, do not top it off.
Record mileage
Drive car till gauge is exactly at 3/4 tank
Record mileage.
Fill tank back up without top off
Take how many gallons used between full and 3/4th and take that and divide it into miles driven and you get mpg. Do this for several different driving styles, and mark down the one that got you the most and how you did it.
I HIGHLY recommend you do not FILL your take with something, you will ruin not only your tank, but your pump and sock as well.
This will give you a very close estimate of MPG doing this way and nothing gets ruined
If you need to get the absolute best MPG you do not use cruise control. Instead you get car up to speed and hold you foot still, even if you are heading up and incline, do not give it any more then what you gave it on flat land, and when you come down off incline/hill, let off the gass and cruise, and it will coast back to your speed limit, and at which point when road is flat, find that spot once again and repet. Granted you may piiss other behind you when you drop a lousy 5mph up a hill, but the goal here is to get the best mpg not make friends, and why no cruise control is because it will increase fule to keep you at speed going back up, and thats bad. This is the best way to get kick ass MPG, and why I can get over 20mpg in my astro van with a fitted L98 Corvette 350 under the hood. It all comes down to learning how to do what I mentioned and everyones car will all of sudden be getting 30mpg or more, or more it was rated for doing