Prometheus was probably doomed, but if it's makers had at least had a shred of courage to follow through on at least some sequences it might have been "good" doomed instead of "bad" doomed.
The two guys that everyone (rightfully) bitches about are a perfect example. If the filmakers had the balls to follow the "pot" angle to any sort of depth and show the two idiots going off and getting completely fucked-up, falling-over-each-other high everything that happens to them afterwards would have been (somewhat) acceptable and made (a litle bit of) sense.
But no - that's too much for the team that made this ham. Pot? but...but.. that might piss some people off! We can't go any farther in that direction. Be thankful we even mentioned it at all.
Here's an idea for them, free of charge: Have the two guys get so high they start hallucinating (maybe the cryosleep had the effect of making them more sensitive to the weed). That could explain why they got lost.
Then - have them see the visions, and make us guess what was real and what wasn't, or whether they even happened at all.