I dunno. The majority of space I use is music and video. I drag those straight to the microSD. In fact, I loaded it up before inserting it into my phone. And my music apps detect it just fine afterward so it's not like I had to do anything "power user"-like.
The only scenario that's a problem is if you have a lot of large games. You'd need to be the hardcore type though because you can install a hundred of the standard games (not even casual) that only take up 50-100MB each.
The thing is those games and apps aren't getting any smaller and we've been stuck on 16GB as a base for 4-5 years now. Ridiculous.