Originally posted by: QueBert
The Vantech has a SATA header for people who don't have MB's with eSATA ports on them, which is most people. So you wouldn't have to run the SATA cable from your MB outside your case. Just to the bracket, then run a SATA cable from the encloser to the bracket. 30 bucks is a awesome price for that. It's a very well built unit, I want to order it myself.
I can't imagine there being any reason why running a SATA cable from your case to an external SATA encloser would be harmful, I am plenty PC Ghetto and it sounds along the lines of a "mod" I would attempt
The Vantech I linked to is for a user who wants the flexibility of connecting SATA or USB. Both plugs are on the back. For your main computer, it comes with a SATA to eSATA bracket. So for me, when it's connected to my main computer, it will be eSATA. But I have the flexibility to pretty much any computer with the USB option. How cool is that? Just ordered it.
The off topic post I linked to above has additional support that plugging straight into an internal SATA port is fine.