With the Sam Raimi series, I was seriously hoping the continuation of that world would bring about The Lizard, because that's exactly where it was beginning to point. It had all the buildup for him, as it was the teacher for so long, a big respected figure for Spidey. And then his research was taking him toward the point of testing tissue-growth on himself, basically it was hinted strongly in Spiderman 3 that The Lizard would be next.
But the next Spiderman movie is completely scrapping all of that story, and they are still just straight into the Lizard? He's still going to be highschool spidey all over again, and they're going to jump right into The Lizard's story.
Meh.
And I'm still pissed at Raimi basically hating Venom - he stated all the time he wanted to get Venom out of the way and completely forget about him as a villain.
Venom is the best villain in the series imho. Such an awesome, comic-book style villain - the complete polar opposite character, which is what made it so intriguing and fun. And I feel they treated Venom fairly well in Spiderman 3, at least for the minimal screen time he had.
Hopefully the new series revisits Venom, otherwise I really won't care about the franchise.