The aliens may well not have the same notions of mortality or individual preservation as we do. Maybe they wouldn't think of a multi-generational ship as a big deal. "So the ones who launch with it will be dead by the time it gets where it's going. So what?" Or maybe they will have the ability to enter a state of suspended animation more easily than us, whether it's brought on naturally or artificially.
And that may well be the case - for our species.
Evolutionary influences from the past have great influence on our daily behavior, including our tendency toward stagnation without some significant competing motivator. Maybe another sentient species wouldn't have such influences, or maybe they'll have gone to the extent of modifying their own genome (or whatever it is they've got) to tweak some of these behaviors, for better or for worse.
And maybe there's an alien LulzSec group out there who just likes to troll the rest of the galaxy by occasionally screwing with the development of other star systems. One system is broadcasting signs of primitive sentient life? Time to see how they cope with some stress - send a pod to the broadcasting planet with a few billion self-replicating nanobots, whose sole purpose is to consume the planet and turn it into a giant
trollface.