I am really interested in extreme scenarios like running 4 290X, and what would actually be better, an AMD 8 core or and Intel 4 core (8 threads). Assuming there would a CPU bottleneck to begin with.
An Intel chip will be better because they are simply faster in most games with their superior IPC. The reason the FX8350 does better than any i5 Intel chip is because BF4 actually takes advantages of multiple cores/threads, which most games do not.
Take a look at the valley benchmark thread on this forum. An overclocked 4960X bottlenecks 3 way Titans at 1080p. It would do the same for 4 way 290X at 1080p as well as even at 1600p I would guess. If you were chasing 120FPS at 1440p with such a setup, then I could see some benefit from Mantle for such an extreme rig. Otherwise I doubt it.
The benchmark from DICE is the one that interests me most. They show a 25% performance gain on an FX8350 & 7970 system in Battlefield 4 with Mantle,
http://cdn.overclock.net/1/1e/900x900px-LL-1e8cb8de_wbbXob.jpeg. The FX8350 = i5 4670K in the game....
...so there could be some real tangible gains there for a lot of setups. I have a 4670K + 7950 system which if that pans out should see a big boost in performance.
As far as high end multi-GPU systems, I think the big Mantle gains will be had if you are gaming at 120hz. If you're on a high resolution 60hz monitor with multiple 290/290x and a fast CPU, I doubt it will make a difference.
A game I'd really like to see Mantle used in is Starcraft 2. Even with huge GPU power that game will give you low FPS with a lot going on at once. It is poorly threaded like all Blizzard games and gobbles up CPU. The same is true for World of Warcraft in a high activity circumstance, another game it would be interesting to see Mantle used in.