I'm ~7 hours into a second play through with listen mode off and it's quite a different experience. Way more unpleasant surprises, but on the upside they serve to highlight something in the game that I didn't experience nearly as much with listen mode on: Ellie assisting/stunning enemies and watching my blind spots.
I'm also using the bow a lot this time through, and it's such an awesome weapon that I'm disappointed I barely touched it before. In addition to that, an obvious one to anyone but a casual gamer like me, I've been proactively using the many options the controls grant you: Quick turn around, special combo prompts, the auto-aim head shot when you knock an enemy down, and so on. And lastly, the nicest thing about this play through is I'm pacing myself and making an effort to explore the environments more thoroughly. It's kind of surprising how much detail is crammed into the game. There's really a lot to explore and (most of the time) you're rewarded for it, be it with items or some new dialogue.