I've only had 1 crash so far (20+ hours of play), which occured during a cutscene. Every other time that cutscene ran, it was fine. I'm using Windows XP, so indeed it's a Vista issue.
If you have Vista, you should probably wait a month or two until this is resolved. If you still have an XP install somewhere, go for it.
The frequent loads are annoying, no denying it, especially since every house needs to be loaded, and then the outside map re-loaded when you leave. There must be a better way to do this. They should always keep the outside map in memory to avoid this.
In the end, I actually prefer this game to either Gothic or KotOR. The story has much more of an adult theme with contexts that you'd more likely find in the real world, which don't dwell on the whole good vs. evil thing that has been overused by most RPGs (see Bioware).