Be sure it's the psu fan before getting in very deep- more often than not, the cpu fan is to blame.....
If the fan is noisy, making scraping sounds, etc., it's defective and should be returned/replaced. If it's loud, running at high speed, then the temp control circuit may be defective, sending the fan to high speed all the time. Check this by unplugging the case fans and giving the system a workout, the fan should speed up as the system warms.
The Antec 300w supplies are usually quiet, this does not mean silent. Peeps moving up from much older systems with 200-235w supplies may notice the increased noise more than others.
There are some tricks to reduce the noise, like replacing stamped grilles with wire grilles, and switching to quieter (lower cfm) fans. Depends on how involved you want to get, and how anxious to void the warranty....