firewire is faster, but USB is used more often by far. if you get a USB enclosure its always backwards compatable so you can use it on just about ANY computer.
They are both fine for all intents and purposes. As was said, USB 2.0 offers faster speeds. Theoretically. Real-world performance shows IEEE1394 is faster. I doubt the difference would be all that significant however. If you need to ensure compatability against a large number of computers, USB. Otherwise, it really doesn't matter all that much. Go with both or pick one.
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