This is better than the drug compunds like Hertnu etc that have proven to be ineffective beyond 3 yrs.
7-27-2005
Genes linked to spread of breast cancer discovered
LONDON - Scientists have identified genes enabling breast cancer cells to spread to the lungs, a discovery that could improve diagnosis and treatment of the disease.
The set of genes not only reveals where the cancer will spread, but also how virulent it is likely to be. The genes could be potential targets for existing or new breast cancer drugs, according to the researchers.
Massague and his team discovered the pattern of gene activity by studying tumors from 82 patients whose breast cancer had spread to the lungs.
They analyzed data from a similar group of patients from the Netherlands and found the same genetic signature.
Massague said the genes were not just markers for cancer spreading, but were also mediators that caused it to spread. The proteins they produced could become prime targets for existing or new drugs to prevent metastasis -- the spread of cancer.
"Compounds already exist to block some of the genes we have identified or the cell function they regulate. The next step is to begin testing these compounds in animal models to see if they can block metastasis," Massague said.
If someone is diagnosed with cancer and the tumor is found to have the genes, doctors may be able to provide drugs preventively, or at least have them ready for whenever the metastasis is detected.
The scientists believe the technique could be expanded to pinpoint genes involved in the spread of breast cancer to other organs or other types of cancer.
"We have already identified a set of genes that mediate metastasis to the bone," said Massague.