How loose is loose? If the PC literally has not been moved at all, then my guess would be vibration. There are vibrations from fans and from the hard drive itself, however minimal they may be.
I dont see any big mystery here. Lots of things could have caused it to come loose. Vibrations, maybe somebody bumped the case (do you have kids or pets?), maybe even contracting and expanding from temperature changes inside the case.
Computers have fans, Hard Drives, and DVD Drives that all vibrate. Sometimes a whole house can vibrate when large trucks go by like a Semi Trailer, a trash truck, or a large salt truck or snow plow.
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