The very first thing I would do is buy an airplane and a large conveyor belt.
I would quit my job in exactly the same fashion that Bond does in Casino Royale -- on a boat in the Mediterranean with a Bond caliber girl, same email he used too.
Buy the two old companies I've worked at (not my current one), fire everyone I didn't like, or who was incompetent, hire better people in their places, then either sell them off or let them be.
I would gather up a team of specialists of all branches of science (plus a couple other non-science members); an astronomer, a mathematician, a zoologist, a plant specialist, marine biologist, zoologist, historian, and an anthropologist, a wildlife survival specialist, and a writer. With this team assembled I would fund an HD show to be aired on PBS HD, that would be a documentary of our travel across the world, every continent, all major cities, historical sites, and ecologically interesting places on the planet. Each member would get chances to share their knowledge, and have freedom to decide the places we visit and the themes for each episode. The show might last several seasons and the team could rotate as their schedules allowed. I would tag along most of the time as well.
Find a hot girlfriend, take her with me everywhere. I would vacation a lot, but I'd need something to keep me busy so I might go back and get an advanced degree in math, physics, or perhaps multiple. Also one in some kind of visual art, probably architecture. I would buy properties in Greece, France, England, Brazil, Japan and the United States. Homes would all be top notch, with nice audio systems and home theater setups, and all right on the beach, or in sight of. I might also start a hardware site. I could code it all myself, and write custom load tests for enterprise class hardware (high end networking equipment, NAS, SAS, load balancers, CPU & storage tests for high end database and web app setups, etc). I always liked doing performance tests, both for code and hardware so I'm pretty sure I'd enjoy that.
I would try to set up a fund that would pay anyone who votes for president $10 for the next 5 US Presidential elections.
Lifetime courtside Laker tickets. A few luxury cars, a private jet. Go halvies on the Nets with Jay-z.