She's a sharp cookie. 34 on her ACT (we don't do SAT).
That is a very high score. At a good medical school, that's the norm. I've had undergrads who scored 32+ on their ACT tell me medical school makes what they did as an undergrad seem like child's play. Anyone who is telling her that medical school coursework will be "pretty simple" because she's a pharmacist simply does not know what they are talking about. Period.
No one finds medical school "pretty simple." That kind of arrogance and/or ignorance is breathtaking.
You should heed the words of the folks in this thread who are in medical school. My sister just graduated from a good medical school, and would tell you the same things they are. She'd also tell you that of the six non-trad married with children students who started with her, five finished, one with their marriage intact (possibly due to the kids being in high school).
If your wife thinks that inept managers and weak administrators who buckle to shit doctors will cease being an issue when she's an ER physician, she's mistaken. These are often hospital-specific cultures. My father is a physician who tries very hard to minimize his involvement with certain hospitals - because of inept managers and bad doctors. My sister chose her residency primarily on its culture (or rather, didn't go where she didn't like the environment). Whether you're a Pharm.D or a physician, you have to deal with the negative aspects of a hospital. I wonder if a change of employer might be a better solution to these problems than a different career.
Clearly your wife is good at what she does: people come to her for help, which is very high praise. Yet it seems she's insecure about it - otherwise she'd dismiss doctors telling her that she could be doing something 'more.' Especially when ED doctors tell her that. Surely she knows that the ED is not where you generally find the sharpest physicians? If she's vulnerable to that type of suggestion now as a Pharm.D, what's going to happen when people comment 'I wonder why she's not a cardiologist or neurologist instead of a emergency doctor?'
Finally, given the trends in physician pay, you're naive if you think physicians will be making the same amount of money in 10, 20, and 30 years that they are now. The average ER doctor today makes about $250,000/year. That number will be going down. Your wife already makes $125,000/year. That number will not be going down. The best case is that the difference stays about the same (an unlikely best case). If your wife is in her early thirties, she'll have about 20 years at full physician salary after med school and residency. That's about $2 million more as a doctor than pharmacist. Now subtract from that the seven years her income will be close to zero vs. $125k/year if she stayed in pharmacy. You're down to about $1.2 million more as the doctor. Now subtract the out of pocket cost of med school, and you're down below a million. Now subtract the cost of interest on loans, and you're approaching $750,000. What about the decreased value of retirement funds like 401k etc that would be lost?
This is basically the most important decision you and your wife are likely to make in the rest of your lives. Good luck.