Contributing for those who loves the insane action that Serious Sam games provide.
Specs in sig.
AMD drivers installed
nForce 6.66 system drivers & AGPgart from UDP 5.10
Catalyst 5.4
DirectX 9.0c
Problem: Audio skips and problems at cinematics, mouse would erratically jump from one point to another while trying to navigate the menu. At that point I made my way, albeit slowly, over to the 'Exit' option to quit.
Resolution: Set affinity by however means necessary (ie via TaskManager, runfirst, WinLaunchXP, etc). After that, it cleared up and no problems at all.
Gotta love CroTeam. Now if they can just adapt their engine and game to be more... *ahem* friendly to multi-core/HT.