As much as I love my boys in Pitt I can't see them pulling out a win against the Jags. The loss of Aaron Smith at DE has devastated their ability to stop the run. The Jags exploited that hole a couple of weeks ago and will do so once again, look for them to have major success running to the left side.
Pitt's O-line problems have only gotten worse. Weakest point has been left tackle, their backup max Starks was lost for the season in the game against Baltimore. They are down to the 3rd string guy there, and only have one other healthy linemen. There has been some talk that they will move Alan Faneca to left tackle, probably not a bad idea but it still leaves a 3rd (Trei Essex) stringer at left guard.
They seem to have finally fixed their return coverage issues, but that's a moot point considering the problems they have on offense/defense at this stage in the game. It's amazing Ben had such a great season given the poor protection all year, but I don't think he's gonna be able to do enough to get it done against a stout Jags team.