When Elaine borrows Jerry's car to haul trash, is driving on Kramer's mile of highway in the luxuriously wide lanes, swerves around, loses the sewing machine, and Newman catches it on the undercarraige of his truck, drags it to where Kramer is using the flammable paint thinner to dissolve the black paint on the highway lines, sparks up the paint thinner, and yells out:
"OH THE HUMANITY!!!"
or, any use of the line:
"Aw, that's a shame."